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. 2018 Feb 2;9:156. doi: 10.3389/fimmu.2018.00156

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Copyright © 2018 Seliga, Lee, Fernandes, Zuluaga-Ramirez, Didukh, Persidsky, Potula, Gallucci and Sriram.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bradykinins (BKs) suppress interferon-stimulated genes in splenocytes in vivo and in ex vivo mouse dendritic cells (DCs). (A) B6 and Sle mice were injected with CpG-A intraperitoneally for overnight stimulation, BK was administered retro-orbitally for 2 h and expression of the IFN-inducible genes was analyzed from total splenocytes by real-time qPCR. All of the conditions were calibrated against the untreated control in each experiment. Graphs are averages of three independent B6 mice sets (A) and one representative Sle set (B). (C) DCs from B6 mouse spleen were sorted by Miltenyi magnetic beads, plated in 24-well plates, stimulated with CpG-A (2 h) followed by BK (3 h) and analyzed for Ifn-β expression. Line graphs are fold change in gene expression normalized to untreated control in each experiment; *p < 0.05.