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. 2018 Feb 2;8:23. doi: 10.3389/fcimb.2018.00023

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Copyright © 2018 Nguyen, Röttgerding, Devraj, Lin, Koenigs and Kraiczy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of the CbiA-plasminogen interaction. To determine the effect of the lysine analog tranexamic acid or increasing ionic strength on the CbiA-plasminogen interaction, CbiA, BBA70 (positive control), and DbpA (negative control) (5 μg/ml each) were immobilized and incubated with plasminogen in the presence of increasing concentrations of tranexamic acid (A,B) or NaBr (C,D). Bound plasminogen was detected using a polyclonal antibody (1:1,000) and binding of plasminogen to CbiA and BBA70 in the absence of tranexamic acid or NaBr was set to 100%. Data represent means and standard deviation of at least three independent experiments, each conducted in triplicate. ****p ≤ 0.0001, one-way ANOVA with post-hoc Bonferroni multiple comparison test.