Table 1.
Transplantation characteristics by donor Interleukin-7 receptor α-chain genotype rs6897932.
| Characteristics | CC (n = 252) | CT (n = 178) | TT (n = 30) | P-value |
|---|---|---|---|---|
| Age at transplantation (years), median (range) | ||||
| Recipients | 25.4 (0.4–63.0) | 27.8 (0.3–60.0) | 27.6 (0.9–50.6) | 0.61 |
| Donors | 34.0 (2.8–71.6) | 33.0 (1.1–59.5) | 35.6 (16.1–60.8) | 0.27 |
| Disease at transplantation, no. of patients (%) | ||||
| Acute myeoloid leukemia | 78 (31%) | 50 (28%) | 8 (27%) | 0.89 |
| Acute lymphoblastic leukemia | 62 (25%) | 48 (27%) | 8 (27%) | |
| Other malignancies | 65 (26%) | 43 (24%) | 10 (33%) | |
| Benign disorders | 47 (19%) | 37 (21%) | 4 (13%) | |
| Donor type, no. (%) | ||||
| HLA-identical. siblings | 78 (31%) | 57 (32%) | 12 (40%) | 0.81 |
| HLA-matched unrelated donors | 133 (53%) | 97 (54%) | 14 (47%) | |
| HLA-mismatched unrelated donors | 41 (16%) | 24 (13%) | 4 (13%) | |
| Stem cell source, no. (%) | ||||
| Bone marrow stem cells | 181 (72%) | 130 (73%) | 18 (60%) | 0.34 |
| Peripheral blood stem cells, G-CSF mobilized | 71 (28%) | 48 (27%) | 12 (40%) | |
| Total nucleated cell dose infused ×106/kg recipient wt, median | 4 | 3.6 | 5 | 0.29 |
| Conditioning regimen, no. of patients (%) | ||||
| TBI + CY or Etoposide | 156 (62%) | 116 (65%) | 21 (70%) | 0.61 |
| Chemotherapy alone | 96 (38%) | 62 (35%) | 9 (30%) | |
| Anti-thymocyte globulin as part of conditioning regimen, no. (%) | ||||
| Yes | 105 (42%) | 65 (37%) | 9 (30%) | 0.34 |
| No | 147 (58%) | 113 (63%) | 21 (70%) | |
| Sex-mismatch (female donor to male recipient), no. (%) | ||||
| Yes | 37 (15%) | 27 (15%) | 7 (23%) | 0.46 |
| No | 215 (85%) | 151 (85%) | 23 (77%) | |
| CMV IgG mismatch, no. (%) | ||||
| Yes | 91 (36%) | 61 (34%) | 10 (33%) | 0.86 |
| No | 161 (64%) | 117 (66%) | 20 (67%) | |