Table 2.
Longitudinal T cell reconstitution by donor Interleukin-7 receptor α-chain genotype.
Univariable model [estimate (95% CI)] | Multivariable model [estimate (95% CI)] | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
CC | CT | P-value (CT versus CC) | TT | P-value (TT versus CC) | CC | CT | P-value (CT versus CC) | TT | P-value (TT versus CC) | |
Day +30 | ||||||||||
CD3+ | 1.0 | 0.90 (0.61–1.32) | 0.59 | 1.37 (0.71–2.64) | 0.34 | 1.0 | 0.94 (0.67–1.33) | 0.75 | 1.04 (0.57–1.90) | 0.89 |
CD4+ | 1.0 | 0.97 (0.69–1.37) | 0.85 | 1.68 (0.93–3.05) | 0.088 | 1.0 | 1.03 (0.77–1.38) | 0.86 | 1.27 (0.76–2.10) | 0.36 |
CD8+ | 1.0 | 0.91 (0.61–1.38) | 0.67 | 1.19 (0.58–2.44) | 0.63 | 1.0 | 0.95 (0.64–1.41) | 0.79 | 0.96 (0.48–1.92) | 0.92 |
Day +60 | ||||||||||
CD3+ | 1.0 | 1.16 (0.81–1.67) | 0.42 | 2.37 (1.29–4.35) | 0.006 | 1.0 | 1.20 (0.86–1.67) | 0.30 | 2.09 (1.20–3.66) | 0.0097 |
CD4+ | 1.0 | 1.08 (0.78–1.50) | 0.63 | 1.94 (1.13–3.37) | 0.017 | 1.0 | 1.13 (0.86–1.50) | 0.38 | 1.64 (1.03–2.61) | 0.038 |
CD8+ | 1.0 | 1.24 (0.83–1.86) | 0.29 | 2.53 (1.29–4.96) | 0.007 | 1.0 | 1.26 (0.85–1.86) | 0.24 | 2.33 (1.21–4.47) | 0.011 |
Day +90 | ||||||||||
CD3+ | 1.0 | 1.02 (0.73–1.44) | 0.89 | 1.36 (0.70–2.64) | 0.36 | 1.0 | 1.02 (0.74–1.39) | 0.91 | 1.22 (0.66–2.27) | 0.53 |
CD4+ | 1.0 | 0.99 (0.74–1.34) | 0.97 | 1.53 (0.85–2.73) | 0.16 | 1.0 | 1.01 (0.78–1.30) | 0.96 | 1.28 (0.77–2.15) | 0.34 |
CD8+ | 1.0 | 1.03 (0.71–1.51) | 0.86 | 1.35 (0.64–2.83) | 0.43 | 1.0 | 1.03 (0.71–1.48) | 0.89 | 1.26 (0.61–2.59) | 0.53 |
Day +180 | ||||||||||
CD3+ | 1.0 | 1.00 (0.74–1.36) | 0.99 | 0.94 (0.55–1.59) | 0.81 | 1.0 | 0.99 (0.74–1.33) | 0.95 | 0.86 (0.52–1.43) | 0.56 |
CD4+ | 1.0 | 0.98 (0.75–1.28) | 0.86 | 1.13 (0.71–1.80) | 0.61 | 1.0 | 0.97 (0.76–1.23) | 0.80 | 1.01 (0.66–1.53) | 0.97 |
CD8+ | 1.0 | 0.94 (0.66–1.35) | 0.74 | 0.80 (0.43–1.49) | 0.48 | 1.0 | 0.93 (0.66–1.33) | 0.71 | 0.76 (0.41–1.40) | 0.38 |
Day +360 | ||||||||||
CD3+ | 1.0 | 0.97 (0.72–1.31) | 0.83 | 0.93 (0.53–1.63) | 0.79 | 1.0 | 0.94 (0.71–1.24) | 0.67 | 0.91 (0.54–1.55) | 0.74 |
CD4+ | 1.0 | 0.92 (0.67–1.25) | 0.59 | 1.04 (0.58–1.86) | 0.90 | 1.0 | 0.89 (0.68–1.16) | 0.38 | 0.98 (0.59–1.63) | 0.95 |
CD8+ | 1.0 | 0.98 (0.69–1.39) | 0.90 | 0.87 (0.45–1.66) | 0.67 | 1.0 | 0.95 (0.68–1.34) | 0.77 | 0.86 (0.45–1.63) | 0.64 |
Significant associations are written in bold.