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. 2018 Feb 2;12:40. doi: 10.3389/fnins.2018.00040

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Copyright © 2018 Satta, Scherma, Piscitelli, Usai, Castelli, Bisogno, Fratta and Fadda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endocannabinoid levels: data are presented as mean ± SEM (n = 6 rats per group). (A) AEA: HR group showed a decrease in Caudate Putamen, Amygdala and Hippocampus compared to CTRL group (one-way ANOVA: ^*P < 0.05 and ^**P < 0.01, Newman–Keuls test vs. CTRL); LR group showed a decrease in Prefrontal Cortex and Amygdala as well as an increase in the Nucleus accumbens compared to CTRL group (one-way ANOVA: ^*P < 0.05 and ^**P < 0.01, Newman–Keuls multiple comparison test vs. CTRL group). (B) 2-AG: both LR and HR groups showed an increase compared to CTRL group in the hippocampus (one-way ANOVA: ^**P < 0.01, Newman–Keuls test vs. CTRL group).