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. 2018 Feb 2;12:40. doi: 10.3389/fnins.2018.00040

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Copyright © 2018 Satta, Scherma, Piscitelli, Usai, Castelli, Bisogno, Fratta and Fadda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endocannabinoid-like compounds levels: data are presented as mean ± SEM (n = 6 rats per group). (A) OEA: both LR and HR groups showed a decrease in the hypothalamus compared to CTRL group (one-way ANOVA: ^**P < 0.01, Newman–Keuls test vs. CTRL group). LR group showed an increase in the Prefrontal Cortex compared to CTRL group (one-way ANOVA: ^**P < 0.01, Newman–Keuls test vs. CTRL group). (B) No changes in the levels of PEA were found between all three experimental groups.