Table 1.
Effects of MRA therapy on LV remodeling, NYHA class and diastolic function in patients with heart failure and reduced ejection fraction.
LVEF (left ventricular ejection fraction), LVESVI (left ventricular end-systolic volume index), LVEDVI (left ventricular end-diastolic volume index), E (peak velocities of early mitral inflow), DT (E wave deceleration time). WMD indicates weighted mean difference.
| Author | Time | LVEF (%) (WMD) | NYHA functional class (WMD) | LVESVI (mL/mq) (WMD) | LVEDVI (mL/mq) (WMD) | E (cm/s) (WMD) | DT (ms) (WMD) |
|---|---|---|---|---|---|---|---|
| Barr et al. [95] | 8 weeks | 20 ± 6 → 19 ± 6 (P = NS) | – | – | – | 57 ± 4 → 51 ± 6 (P = NS) | – |
| Tsutamoto et al. [96] | 4 months | 32.2 ± 2.2 → 35.0 ± 1.9 (P < 0.05) | 2.3 ± 0.1 → 1.9 ± 0.1 (P = 0.002) | – | 192 ± 11 → 178 ± 10 (P < 0.05) | – | – |
| Cicoira et al. [97] | 12 months | 33 ± 7 → 36 ± 9 (P < 0.01) | – | 188 ± 94 → 171 ± 97 (P < 0.01) (not indexed) | 275 ± 104 → 251 ± 105 (P < 0.01) (not indexed) | 62 ± 21 → 59 ± 21 (P = NS) | 217 ± 93 → 219 ± 67 (P = NS) |
| Akbulut et al. [98] | 12 weeks | 28.9 ± 6.1 → 36.3 ± 8.3 (P < 0.01) | – | – | – | – | – |
| Kasama et al. [88] | 6 months | 33 ± 6 → 39 ± 6 (P < 0.005) | 2.8 ± 0.4 → 1.7 ± 0.5 (P < 0.0005) | – | 187 ± 26 → 154 ± 41 (P < 0.005) (not indexed) | – | – |
| Ozkara et al. [99] | – | ||||||
| Kasama et al. [100] | 6 months | 32 ± 6 → 43 ± 11 (P < 0.001) | 2.6 ± 0.5 → 1.9 ± 0.7 (P < 0.001) | 131 ± 30 → 95 ± 29 (P < 0.001) (not indexed) | 192 ± 32 → 165 ± 30 (P < 0.001) (not indexed) | – | – |
| Gao et al. [86] | 6 months | 42 ± 11 → 46 ± 13 | – | – | – | – | – |
| Chan et al. [47] | 52 weeks | 26 ± 2 → 35 ± 3 (P < 0.01) | 2.0 ± 0.6 → 1.5 ± 0.5 (P < 0.001) | 120.30 ± 14.74 → 88.14 ± 17.10 (P < 0.01) | 154.68 ± 14.21 → 121.10 ± 15.76 (P < 0.01) | 77 ± 6 → 62 ± 4 (P < 0.05) | 216.87 ± 21.81 → 251.89 ± 15.71 (P = NS) |
| Boccanelli et al. [20] | 12 months | 39.9 ± 8.6 → 45.1 ± 9.6 (P < 0.05) | – | – | 156.8 ± 54.5 → 128.2 ± 44.6 (P < 0.05) (not indexed) | – | – |
| Taheri et al. [101] | 6 months | 31.3 ± 8.8 → 41.2 ± 9.6 (P = 0.01) | – | – | – | – | – |
| Udelson et al. [46] | 36 weeks | P = NS | P = NS | P = NS | P = NS | – | – |
| Vizzardi et al. [45] | 6 months | 34.6 ± 9.8 → 38.4 ± 6.3 (P < 0.001) | – | 114.5 ± 5.6 → 96.9 ± 9.0 (P < 0.001) (not indexed) | 173.2 ± 28.9 → 155.9 ± 4.2 (P < 0.001) (not indexed) | 57 ± 54 → 37 ± 14 (P < 0.001) | 236 ± 106 → 273 ± 70 (P = 0.001) |
| Kimura et al. [102] | 12 months | 34 ± 6 → 37 ± 8 (P = NS) | – | – | 61 ± 4 → 59 ± 5 (P < 0.05) | – | – |