TABLE 1 .
Mean thickness of C. albicans cell wall, measured in 10 TEM medial sections, in comparison with sensitivity to AmBisome measured at 24 h and 48 h
| Strain | AmBisome IC50 (µg/ml) at time: |
Cell wall thickness (nm) ± SDa |
||
|---|---|---|---|---|
| 24 h | 48 h | Outer wall | Inner wall | |
| Wild type | 1 | 2 | 77 ± 15 | 76 ± 17 |
| pmr1Δ mutant | 0.5 | 1 | 46 ± 9 | 56 ± 23 |
| och1Δ mutant | 2 | 4 | 6 ± 0.8 | 230 ± 29 |
| mnn4Δ mutant | 0.5 | 2 | 79 ± 9 | 77 ± 23 |
| mnt1Δ/mnt2Δ mutant | 1 | 1 | 34 ± 5 | 50 ± 17 |
| chs3Δ mutant | 0.25 | 0.5 | 81 ± 20 | 42 ± 9 |
a
The outer wall refers to the mannoprotein fibrillar fringe, and the inner wall refers to the glucan-chitin amorphous layer.