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. 2017 Nov 22;191(3):288–300. doi: 10.1111/cei.13073

Figure 4.

Figure 4

Regulatory function of natural killer (NK) cells is impaired in systemic lupus erythematosus (SLE) patients and depends upon disease activity. Co‐culture of NK cells and carboxyfluorescein diacetate succinimidyl ester (CFSE)‐labelled immature or mature dendritic cells (DCs) were performed for 24 h at different ratios; the percentage of dendritic cell survival corresponds to CFSE+ cells. (a) Percentage of immature DC survival following co‐culture with NK cells from active, remission and control subjects for 24 h at different ratios. (b) Comparison of the percentage of DC survival between the three groups. (c) Results of the percentage of mature DC survival at 24 h from active, remission and control subjects are displayed. (d) Comparisons between the three groups. Data are shown as the median and interquartile range. Controls are displayed in white bars, remission patients in grey bars and patients with SLEDAI > 4 in black bars. *P < 0·05; **P < 0·005; ***P < 0·0001.