Fig. 5.

Necrotic fibers and macrophages quantitated as a function of drug levels in serum. As in Fig. 3, but for the values for necrotic fibers and macrophages measured as in Fig. 4. (A–D) Data for necrotic fibers show that increasing concentrations of ibuprofen are associated with a trend to increased necrosis (A). (E–H) Ibuprofen tends to increase macrophage infiltration to a small extent at higher concentrations with or without ISDN. None of the changes shown reach significance, however. Lines are best fits by linear regression. Dashed curves represent the 95% confidence interval of the best-fit line.