Fig. 7.

Volumes and composition of hind limb muscles after long-term treatment with ibuprofen. Volumes and fat and water contents were measured by MRI when mice were 12 months of age. (A and B) Volumes of the gluteus (A) and psoas (B) muscles were significantly reduced in the BlAJ mice compared with C57BL/6J controls, but were not affected by ibuprofen. (C and D) Fat (C) and water (D) contents of gluteus muscles elevated (fat) or diminished (water) in BlAJ mice compared with C57BL/6J controls, but were not affected by ibuprofen. ***Indicate P < 0.001 for differences between C57BL/6 and BlAJ, with or without ibuprofen treatment.