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Mutant ERα and ERβ LBDs reveal ERα as the dominant heterodimeric partner in the presence of selective ERα/β heterodimer compounds. (A) Heterodimerization of the wild-type ERα and ERβ. (B) Mutation in the ERβ LBD does not affect heterodimerization with ERα. (C) Heterodimerization of mutant ERα with mutant ERβ. (D) No dimerization is observed between mutant ERα and wild-type ERβ. Data are shown as mean ± S.D. * Indicates statistically significant <0.05.
