Fig. 1.

Renal IR induces hepatic steatosis. (A) C57BL/6 male mice were subjected to sham surgery or 30 minutes of bilateral renal ischemia followed by 24 hours of reperfusion. Blood samples were collected to measure serum levels of creatinine and BUN. (B) Renal histology as shown by H&E staining. Original magnification, 200×. Arrow and arrowhead indicate tubular dilation and necrosis, respectively. (C) Macroscopic liver appearance (top) and liver histology as shown by H&E staining (middle) and Oil-Red O staining (bottom). (D) Hepatic and serum lipid levels. (E) Serum ALT, AST, and total bilirubin levels. Results are presented as the mean ± S.D. of five mice per group. *P < 0.05, compared with the sham group.