Table 4.

Ovarian cancer case-case analysis by age at diagnosis.

Gene	Cases < 60 at diagnosis (n = 4132)			Cases ≥ 60 at diagnosis (n = 3564)
	OC cases tested	Cases with P/LP	% positive	OC cases tested	Cases with P/LP	% positive	OR	95% CI	p-Value
ATM	3341	34	1.0	2916	19	0.65	1.57	0.87–2.92	0.11
BRCA1	3975	226	5.7	3451	70	2.0	2.91	2.21–3.88	8.90 × 10−16
BRCA2	3975	121	3.0	3451	129	3.7	0.81	0.62–1.05	0.10
BRIP1	3330	19	0.57	2906	42	1.4	0.39	0.21–0.69	0.0005
MSH2	3928	25	0.64	3421	3	0.09	7.3	2.22–37.8	0.0001
MSH6	3928	43	1.1	3421	5	0.15	7.56	3.00–24.5	4.80 × 10−7
NBN	3330	13	0.39	2906	11	0.38	1.05	0.41–2.71	0.91
PALB2	3350	10	0.3	2929	13	0.44	0.67	0.26–1.66	0.34
RAD51C	3330	29	0.87	2906	21	0.72	1.21	0.66–2.23	0.51
RAD51D	3020	5	0.17	2675	13	0.49	0.34	0.09–1.02	0.03