Table 3.

Multivariable Hazard Ratios (HR) for Abdominal Aortic Calcium (AAC) Density, ln(AAC volume), Coronary Artery Calcium (CAC) Density, and ln(CAC Volume) for Incident Coronary Heart Disease (CHD), Cardiovascular Disease (CVD), and All-cause Mortality (ACM)

	CHD (N=77)		CVD (N=117)		ACM (N=168)
	HR (95% CI)	Pvalue	HR (95% CI)	Pvalue	HR (95% CI)	Pvalue
Model 1
AAC density, per SD	0.70 (0.26, 1.86)	0.47	0.41 (0.16, 1.04)	0.06	0.43 (0.19, 0.95)	0.04*
ln(AAC volume), per SD	1.27 (1.10, 1.45)	< 0.01*	1.34 (1.17, 1.53)	< 0.01*	1.33 (1.19, 1.49)	< 0.01*
Model 2
AAC density, per SD	0.97 (0.34, 2.74)	0.95	0.66 (0.24, 1.80)	0.42	0.46 (0.20, 1.07)	0.07
ln(AAC volume), per SD	1.15 (1.002, 1.33)	0.05	1.21 (1.06, 1.38)	< 0.01*	1.30 (1.15, 1.48)	< 0.01*
CAC density, per SD	0.65 (0.33–1.26)	0.20	0.47 (0.25–0.90)	0.02	0.92 (0.56, 1.53)	0.76
ln(CAC volume), per SD	1.23 (1.08, 1.41)	< 0.01*	1.25 (1.10, 1.41)	< 0.01*	1.04 (0.94, 1.15)	0.44
Model 3 - Adjusted for GFRS, ethnicity, and statin therapy
AAC density, per SD	1.07 (0.36, 3.14)	0.90	0.93 (0.33, 2.57)	0.89	0.57 (0.24, 1.35)	0.20
ln(AAC volume), per SD	1.10 (0.95, 1.28)	0.20	1.14 (1.00, 1.32)	0.06	1.25 (1.36, 1.42)	< 0.01*
CAC density, per SD	0.74 (0.38, 1.47)	0.08	0.55 (0.29, 1.04)	0.07	1.12 (0.66, 1.88)	0.68
ln(CAC volume), per SD	1.17 (1.04, 1.59)	0.02*	1.20 (1.05, 1.36)	< 0.01*	0.99 (0.90, 1.10)	0.91

CHD = myocardial infarction, resuscitated cardiac arrest, or CHD death. CVD = CHD plus non-fatal or fatal stroke.

Global Framingham risk score (GFRS, composite of age, sex, smoking and diabetes status, total and HDL cholesterol, systolic blood pressure and blood pressure treatment). Two-tailed p-value < 0.05 considered significant, ln = natural log.