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. Author manuscript; available in PMC: 2018 Feb 7.
Published in final edited form as: Dev Dyn. 2016 Aug 17;245(10):1011–1028. doi: 10.1002/dvdy.24430

Figure 1. Runx1 and Kit expression in the yolk sac at late head fold stage.

Figure 1

(A–C) A late head fold stage (E8.0) mouse embryo immunostained for CD31 (i), Runx1 (i,ii) and Kit (i,iii). (A) Confocal Z-projection. Proximal (P) and distal (D) axes are indicated in i. Bracket in ii indicates band of Runx1+ cells in the proximal yolk sac. Arrowheads in ii point to Runx1+ cells located distal of the proximal band of Runx1+ cells. Scale bar = 500µm (see Movie 1 for animation of Z-stack). (B) Magnified image of Runx1+ cells in the distal yolk sac. Scale bar = 10µm. (C) Single optical projection showing hematopoietic cells (yellow arrowheads) and hemogenic endothelial cells (white arrowheads) in the proximal band of Runx1+ cells in the yolk sac. Scale bar = 10µm.