Table 2.
Results of the Meta-analysis
| POOLED ANALYSIS | HETEROGENEITY | PUBLICATION BIAS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ES (CI) | P-value | Q | I 2 | P-value | T 2 | T | Egger’s | Begg and Mazdumdar’s | ||||
| T | P-value | Z | P-value | |||||||||
| Cancer vs Healthy Controls | ||||||||||||
| Protein (k = 3) [13,41,39] |
2.91 (1.80;4.70) | < 0.0001 | 1.68 | 0.00 | 0.432 | 0.00 | 0.00 | – | – | – | – | Fig. 1 |
| mRNA (k = 3) [39–41] |
3.93 (2.17;7.15) | < 0.0001 | 2.12 | 5.81 | 0.346 | 0.02 | 0.14 | – | – | – | – | Fig. 1 |
| Cancer vs Normal-Looking Tissue | ||||||||||||
| Protein (k = 6) [9,12,13,17,35,36] |
2.93 (2.21;3.90) | < 0.0001 | 4.42 | 0.00 | 0.491 | 0.00 | 0.00 | −1.10 | 0.334 | −1.32 | 0.188 | Fig. 2a, b |
| mRNA (k = 5) [12,17,34–36] |
2. 80 (1.81;4.32) | < 0.0001 | 9.01 | 55.59 | 0.061 | 0.14 | 0.37 | 0.28 | 0.798 | 0.00 | 1.000 | Fig. 2a, c |
| SURVIVAL | ||||||||||||
| Protein (k = 5) [10,15,35,36,38] |
0.51 (0.37;0.70) | 0.005 | 2.29 | 0.00 | 0.682 | 0.00 | 0.00 | 0.14 | 0.897 | 0.49 | 0.624 | Fig. 3a, b |
| mRNA (k = 2) [11,36] |
0.57 (0.31;1.06) | 0.076 | 1.21 | 17.03 | 0.272 | 0.04 | 0.19 | – | – | – | – | Fig. 3a |