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. 2018 Feb 6;18:147. doi: 10.1186/s12885-018-4058-6

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Prediction of the three-lncRNA signature function. a 588 protein-coding genes co-expressed with AC093850.2, LINC00460 and RP11-366H4.1.1 were selected using Pearson correlation coefficients in the lncRNA expression profiles derived from transcriptome RNA-seq analysis of 15 paired ESCC tissues and adjacent normal tissues. Then the association of the three lncRNAs with 588 protein-coding genes was visualized by software Cytoscape_v2.8.3. GO (b) and KEGG (c) pathway function enrichment analysis for the 588 co-expressed protein-coding genes