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The neuro-endocrine mechanisms of action triggered by DMBA on both Hypothalamo-Pituitary-Adrenal and Hypothalamo-Pituitary-Gonadal axes in the SD female rat: DMBA alters melatonin secretion by the pineal gland, the secretion of GnRH and CRH by the hypothalamus which eventually impacts the pituitary (secretion of FSH, LH, PRL and ACTH), adrenal gland (secretion of corticosterone) and ovary functions (secretion of E2) and the feedback loops.
