Table 5.
Dataset of patient biopsies recruited in the study
| Biopsy | Age | ECOG_PS | Status | T-Downstaging | N-Downstaging | Grade | Stage | Neoadjuvant treatment | Treatment toxicity | Pathological Response | Tumor size | DEK (% positive tumor cells) | Phospho-P38 (% positive tumor cells) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | > 70 | 1 | alive without disease | 0 | 1 | High | III | RDT + FOLFOX | No | Partial | > 3 cm | 3 | 35 |
| 2 | > 60 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 3 | 35 |
| 3 | > 70 | 0 | Death | 1 | 0 | High | III | RDT + FOLFOX | Yes | Minimum | < 3 cm | 7 | 65 |
| 4 | > 70 | 0 | alive without disease | 0 | 1 | Low | III | RDT + 5FU | No | Minimum | > 3 cm | 10 | 80 |
| 5 | > 60 | 0 | alive with desease | 0 | 1 | Low | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 15 | 45 |
| 6 | > 70 | 0 | alive without disease | 1 | 1 | High | III | RDT + FOLFOX | Yes | Partial | > 3 cm | 15 | 80 |
| 7 | > 40 | 0 | alive with desease | 0 | 0 | High | III | RDT + 5FU | Yes | Partial | > 3 cm | 20 | 25 |
| 8 | > 40 | 1 | alive with desease | 1 | 0 | High | II | RDT + 5FU | Yes | Minimum | > 3 cm | 20 | 25 |
| 9 | > 70 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 30 | 45 |
| 10 | > 70 | 0 | alive without disease | 1 | 1 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 35 | 55 |
| 11 | > 70 | 0 | alive without disease | N/A | N/A | High | III | RDT + FOLFOX | No | Minimum | > 3 cm | 35 | 10 |
| 12 | > 50 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 35 | 70 |
| 13 | > 70 | 0 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Partial | > 3 cm | 35 | 25 |
| 14 | > 50 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Minimum | > 3 cm | 35 | 25 |
| 15 | > 70 | 1 | alive without disease | 1 | 1 | High | III | RDT + 5FU | Yes | Minimum | < 3 cm | 35 | 90 |
| 16 | > 60 | 1 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 35 | 90 |
| 17 | > 60 | 0 | N/A | 0 | 0 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 40 | 5 |
| 18 | > 80 | 0 | Death | 1 | 0 | High | III | RDT + 5FU | Yes | Partial | > 3 cm | 40 | 90 |
| 19 | > 70 | 1 | alive without disease | 0 | 1 | Low | III | RDT + 5FU | Yes | Minimum | > 3 cm | 40 | 85 |
| 20 | > 60 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 40 | 65 |
| 21 | > 70 | 2 | alive without disease | 1 | 0 | N/A | II | RDT + 5FU | Yes | Minimum | > 3 cm | 40 | 100 |
| 22 | > 70 | 1 | Death | 0 | 1 | High | III | RDT + 5FU | Yes | Partial | > 3 cm | 45 | 65 |
| 23 | > 80 | 1 | alive without disease | N/A | N/A | High | III | RDT + 5FU | No | Partial | > 3 cm | 45 | 40 |
| 24 | > 70 | 1 | alive without disease | N/A | N/A | Low | III | RDT + 5FU | Yes | Partial | > 3 cm | 45 | 80 |
| 25 | > 80 | 1 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 50 | 80 |
| 26 | > 70 | 1 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 55 | 80 |
| 27 | > 50 | 0 | alive without disease | 1 | 1 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 60 | 80 |
| 28 | > 80 | 1 | alive without disease | N/A | N/A | High | N/A | RDT + 5FU | No | Complete | > 3 cm | 60 | 60 |
| 29 | > 80 | 1 | alive without disease | 1 | 1 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 60 | 75 |
| 30 | > 60 | 0 | alive without disease | 0 | 0 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 60 | 40 |
| 31 | > 50 | 1 | alive with desease | 1 | 1 | High | III | RDT + 5FU | No | Complete | < 3 cm | 60 | 100 |
| 32 | > 60 | 0 | alive without disease | N/A | N/A | High | III | RDT + 5FU | No | Complete | > 3 cm | 60 | 45 |
| 33 | > 40 | 0 | alive without disease | 0 | 0 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 65 | 100 |
| 34 | > 80 | 0 | alive without disease | 1 | 1 | High | III | RDT + 5FU | Yes | Partial | > 3 cm | 65 | 75 |
| 35 | > 80 | 0 | alive without disease | 1 | 0 | High | III | RDT + 5FU | No | Partial | > 3 cm | 65 | 75 |
| 36 | > 80 | 1 | alive without disease | 1 | 1 | N/A | III | RDT + 5FU | Yes | Partial | < 3 cm | 65 | 90 |
| 37 | > 70 | 0 | alive without disease | 1 | 1 | N/A | III | RDT + 5FU | No | Complete | > 3 cm | 65 | 90 |
| 38 | > 70 | 1 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Minimum | > 3 cm | 65 | 15 |
| 39 | > 60 | 0 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Partial | > 3 cm | 65 | 80 |
| 40 | > 60 | 1 | alive without disease | 1 | 0 | High | III | RDT + 5FU | No | Partial | > 3 cm | 65 | 50 |
| 41 | > 40 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | Yes | Partial | > 3 cm | 70 | 60 |
| 42 | > 80 | 1 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Complete | > 3 cm | 75 | 80 |
| 43 | > 70 | 0 | alive with desease | 1 | 0 | Low | III | RDT + FOLFOX | No | Minimum | < 3 cm | 75 | 90 |
| 44 | > 70 | 1 | alive without disease | N/A | N/A | High | III | RDT + 5FU | No | Minimum | > 3 cm | 75 | 75 |
| 45 | > 40 | 0 | alive without disease | 1 | 1 | N/A | III | RDT + 5FU | No | Complete | > 3 cm | 75 | 95 |
| 46 | > 60 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | Yes | Complete | < 3 cm | 75 | 90 |
| 47 | > 80 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 75 | 95 |
| 48 | > 60 | 1 | alive with desease | 0 | 1 | High | III | RDT + 5FU | Yes | Complete | > 3 cm | 75 | 70 |
| 49 | > 70 | 0 | Death | 1 | 1 | Low | III | others | Yes | Minimum | < 3 cm | 80 | 3 |
| 50 | > 80 | 1 | Death | 0 | 0 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 80 | 35 |
| 51 | > 70 | 0 | alive without disease | 0 | 0 | High | III | RDT + 5FU | No | Partial | > 3 cm | 80 | 100 |
| 52 | > 60 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Partial | < 3 cm | 80 | 95 |
| 53 | > 70 | 1 | alive without disease | 1 | 0 | N/A | III | RDT + 5FU | No | Partial | > 3 cm | 80 | 30 |
| 54 | > 60 | 0 | alive without disease | 0 | 0 | N/A | II | RDT + 5FU | No | Partial | > 3 cm | 80 | 10 |
| 55 | > 70 | 1 | alive without disease | 1 | 1 | N/A | III | RDT + FOLFOX | No | Partial | > 3 cm | 85 | 90 |
| 56 | > 80 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 85 | 45 |
| 57 | > 50 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 85 | 75 |
| 58 | > 50 | 1 | alive without disease | 0 | 0 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 85 | 85 |
| 59 | > 60 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 85 | 30 |
| 60 | > 80 | 1 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 85 | 80 |
| 61 | > 60 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 85 | 0 |
| 62 | > 50 | 0 | alive without disease | N/A | N/A | Low | III | RDT + FOLFOX | No | Minimum | > 3 cm | 85 | 100 |
| 63 | > 70 | 1 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Minimum | N/A | 90 | 95 |
| 64 | > 70 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 90 | 85 |
| 65 | > 70 | 1 | Death | 0 | 0 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 90 | 45 |
| 66 | > 50 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Minimum | > 3 cm | 90 | 55 |
| 67 | > 60 | 2 | Death | 0 | 0 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 95 | 100 |
| 68 | > 70 | 0 | alive without disease | 1 | 0 | N/A | II | RDT + 5FU | No | Minimum | > 3 cm | 95 | 85 |
| 69 | > 60 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Partial | > 3 cm | 95 | 80 |
| 70 | > 60 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 95 | 90 |
| 71 | > 70 | 0 | alive with desease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 95 | 75 |
| 72 | > 70 | 0 | alive without disease | 1 | 0 | High | III | RDT + 5FU | No | Complete | > 3 cm | 95 | 75 |
| 73 | > 80 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 100 | 75 |
| 74 | > 50 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 100 | 80 |
N/A Not available, RDT radiotherapy