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. 2017 Dec 19;39(3):1043–1051. doi: 10.3892/or.2017.6166

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Copyright: © Quan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 8. — CM of SCC25 cells induces more differentiation of human osteoclasts. (A) Compared with the CD14⁺ monocytes cultured with cytokines CSF and RANKL, those cultured with CM of SCC25 cells yielded more osteoclasts on days 3 and 6 (arrow, TRAP). IF showed similar results, and greater numbers of F-actin rings were found in both groups on days 3 and 6 (arrow, F-actin). No osteoclasts were observed in the negative control group comprising CD14⁺ monocytes only. Representative photos of TRAP and F-actin staining of osteoclasts. (B) Quantification of osteoclasts and F-actin. Significant differences were found between these 4 groups (*P<0.05).