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. 2018 Jan 10;39(3):967–976. doi: 10.3892/or.2018.6204

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Copyright: © Xiong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Acquisition of oxymatrine resistance induces EMT in CRC cells. (A) The HT29 oxymatrine-resistant cells induced specific morphologic changes consistent with EMT, such as spindle-shaped cells with loss of polarity, increased intercellular separation and pseudopodia (arrows). (B) A significant increased migratory and invasive capacity was observed in HT29 oxymatrine resistant cells compared with parental cells. (C) Western blot assay showed that the E-cadherin protein level was suppressed while vimentin protein level was upregulated in HT29 oxymatrine resistant cells. Error bars represent **P<0.01.