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. 2017 Dec 19;39(3):985–992. doi: 10.3892/or.2017.6164

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Bcl-2 overexpression inhibits the induction of ER-mitochondrial interactions by cisplatin in SKOV3 cells. (A) Colocalization of IP3R and VDAC1 in pc-SKOV3 and Bcl-2-SKOV3 cells after cisplatin treatment (bar, 10 µm). (B and C) Representative transmission electron microscopic photomicrographs of pc-SKOV3 and Bcl-2-SKOV3 cells treated with cisplatin for 24 h (scale bar, 200 nm). White arrowheads indicate ER-mitochondrial contacts. Results are the mean ± SD of three independent experiments. *P<0.05. ER, endoplasmic reticulum.