Table 3.

Meta-regression analysis performed using model weighted by the inverse of the variance

Covariates	Coefficient	SE	RDOR (95% CI)a	P valueb
Study location	0.04	0.15	1.04 (0.75–1.44)	0.79
Overall mortality ≥ 10%	−0.34	0.14	0.71 (0.53–0.96)	0.03
Timing of qSOFA score measurement	−0.53	0.159	0.59 (0.43–0.81)	<0.01
Disease severity	−0.44	0.26	0.64 (0.37–1.12)	0.11

qSOFA Quick Sequential (Sepsis-related) Organ Failure Assessment

^aThe RDOR means the diagnostic OR (DOR) for studies that lacked a particular methodological feature divided by the DOR for studies without the flaw

^bP values from random effects meta-regression using restricted maximum likelihood