Table 4.
Association between GC SNP rs2282679 genotypes and overall and disease free colorectal cancer survival (overall and stratified by tumor molecular phenotype)
| rs2282679 Genotype/Allele | Disease-Free Survival | P interaction c | Overall Survival | P interaction c | ||
|---|---|---|---|---|---|---|
| No. of Eventsa /At Risk |
HR (95% CI)b | No. of Eventsa /At Risk |
HR (95% CI)b | |||
| Total colorectal cancer | ||||||
| AA | 83/245 | 1.00 | 69/245 | 1.00 | ||
| AC | 80/207 | 1.33 (0.94–1.88) | 68/208 | 1.24 (0.85–1.81) | ||
| CC | 16/36 | 1.93 (1.06–3.52) | 13/36 | 1.60 (0.85–3.02) | ||
| P trendd | 0.020 | 0.107 | ||||
| CC + AC (vs. AA) | 96/243 | 1.40 (1.00–1.95) | 81/244 | 1.29 (0.90–1.85) | ||
| CC (vs. AC + AA) | 16/36 | 1.69 (0.95–2.99) | 13/36 | 1.44 (0.79–2.65) | ||
| Per C allele | 1.36 (1.05–1.77) | 1.26 (0.95–1.66) | ||||
| BRAF Val600Glu mutant | ||||||
| AA | 8/20 | 1.00 | 5/20 | 1.00 | ||
| CC + ACe | 8/26 | 0.95 (0.25–3.62) | 7/26 | 1.53 (0.47–4.95) | ||
| BRAF wild-type | ||||||
| AA | 65/200 | 1.00 | 55/200 | 1.00 | ||
| CC + AC e | 83/195 | 1.58 (1.12–2.23) | 0.043 | 70/196 | 1.33 (0.93–1.91) | 0.892 |
| MSI-H | ||||||
| AA | 3/25 | 1.00 | 0/26 | 1.00 | ||
| CC + ACe | 5/28 | 1.26 (0.18–8.96) | 3/28 | NCf | ||
| MSS/MSI-L | ||||||
| AA | 76/204 | 1.00 | 65/204 | 1.00 | ||
| CC + ACe | 87/203 | 1.34 (0.97–1.87) | 0.702 | 74/204 | 1.26 (0.89–1.77) | 0.210 |
Abbreviations: HR hazard rate ratios, CI confidence interval, MSI-H microsatellite instability-high, MSS/MSI-L microsatellite stable/microsatellite instability-low
aEvents are defined as deaths for overall survival and death, recurrence, or metastasis (whichever occurred earliest) for disease-free survival
bMultivariable Cox model adjusted for sex, age at diagnosis, tumor stage at diagnosis, marital status, race, reported chemoradiotherapy, MSI status, BRAF mutation status, tumor location, fruit intake, and body mass index where applicable
cP for interaction is computed with Wald method testing significance of multiplicative interaction term between GC SNP rs2282679 genotype and molecular subtype
dLinear trend tested by modeling the ordinal variables of genotype dose as a continuous variable
eCC and AC genotypes were analyzed jointly because of limited sample size in some subgroups
fNC: not calculated
Those with P < 0.05 are in bold