Table 5.

Association between GC rs2282679 genotypes and overall and disease free colorectal cancer survival stratified by non-genetic dietary factors

	GC rs2282679 genotype		P interaction b
	AA HR (95% CI)a	AC + CC HR (95% CI)a
Disease-Free Survival
Dietary vitamin D (μg/d)
Highest tertile (≥7.1)	1.00	1.65 (0.97–2.82)
Lowest tertile (< 4.6)	1.03 (0.58–1.83)	1.08 (0.56–2.08)	0.191
Dietary calcium (mg/d)
Highest tertile (≥1120.2)	1.00	1.58 (0.92–2.71)
Lowest tertile (< 702.1)	1.06 (0.59–1.91)	1.14 (0.62–2.11)	0.355
Milk (g/d)
Highest tertile (≥274.6)	1.00	1.63 (0.92–1.84)
Lowest tertile (< 128.1)	1.21 (0.68–2.16)	0.97 (0.51–1.84)	0.083
Total dairy products (g/d)
Highest tertile (≥411.8)	1.00	1.51 (0.87–2.60)
Lowest tertile (< 199.2)	1.00 (0.57–1.77)	0.99 (0.53–1.83)	0.289
Overall Survival
Dietary vitamin D (μg/d)
Highest tertile (≥7.1)	1.00	2.11 (1.29–3.74)
Lowest tertile (< 4.6)	1.28 (0.68–2.42)	1.11 (0.54–2.27)	0.040
Dietary calcium (mg/d)
Highest tertile (≥1120.2)	1.00	1.93 (1.08–3.46)
Lowest tertile (< 702.1)	1.55 (0.82–2.91)	1.18 (0.59–2.35)	0.043
Milk (g/d)
Highest tertile (≥274.6)	1.00	2.36 (1.26–4.44)
Lowest tertile (< 128.1)	2.09 (1.09–4.02)	1.26 (0.61–2.62)	0.004
Total dairy products (g/d)
Highest tertile (≥411.8)	1.00	2.03 (1.11–3.72)
Lowest tertile (< 199.2)	1.77 (0.94–3.33)	1.27 (0.63–2.58)	0.024

Abbreviations: HR hazard rate ratios, CI confidence interval

^aAdjusted for sex, age at diagnosis, stage at diagnosis, marital status, race, reported chemoradiotherapy, MSI status, BRAF mutation status, tumor location, body mass index where applicable

^bP for interaction is computed with Wald method testing significance of multiplicative interaction term between GC SNP rs2282679 genotype and respective stratified variable

Those with P < 0.05 are in bold