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. 2018 Feb 6;18:141. doi: 10.1186/s12885-018-4020-7

Fig. 4.

Fig. 4

Whole blood miRNA levels in patients with different breast cancer subtypes at different time points. The box plots show relative levels of the different oncogene miRNAs and tumor suppressors miRNAs in the different patients subgroups analyzed at T0 (a), T1 (b) and T2 (c). The differences were calculated using the Kruskal-Wallis test. Only miR-20a showed a significant difference between the four cancer types after therapy. miR-20a was further analyzed using the Mann-Whitney U test to compare the four different cancer subtypes. A significant difference between luminal cancer type A and B is indicated in the dot plot (d) (*p ≤ 0.05). (T0: before adjuvant therapy; T1: after adjuvant therapy; T2: at 2 years follow up; Lum A: luminal breast cancer type A; Lum B: luminal breast cancer type B; HER2: HER2-like tumor; TN: triple negative breast cancer)