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. 2018 Feb 7;25:10. doi: 10.1186/s12929-018-0405-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Protein expressions of β-arrestin2, ERK, p-ERK, CREB and p-CREB of rats in spinal cord tissues in each group after administration at day 7. Note: A, western blotting image of β-arrestin2, ERK, p-ERK, CREB and p-CREB; B, relative expressions of β-arrestin2, ERK, p-ERK, CREB and p-CREB; N = 8; ^*, P < 0.05 compared with the control group; ^#, P < 0.05 compared with the morphine tolerance group; ERK, extracellular signal-regulated kinase; CREB, cAMP-response element binding protein; NC, negative control