Table 3.
Variable | Level | Total | BRCA1/2 mutation status | P-value | |
---|---|---|---|---|---|
Positive (deleterious and suspected deleterious) | Others (No variant, FP, VUS) | ||||
Age N = 95 | age < =40 | 50 | 13(26.0%) | 37(74.0%) | NS |
age > 40 | 45 | 9(20.0%) | 36 (80.0%) | ||
Triple negative N = 95 | No | 79 | 13 (16.5%) | 66 (83.5%) | 0.001 |
Yes | 16 | 9 (56.3%) | 7 (43.8%) | ||
Triple negative (age < =50 (N = 75)) | No | 60 | 12 (20.0%) | 48 (80.0%) | |
Yes | 15 | 8 (53.3%) | 7 (46.7%) | 0.009 | |
Triple negative (age < =40 (N = 50)) | No | 38 | 7 (18.4%) | 31 (81.6%) | |
Yes | 12 | 6 (50.0%) | 6 (50.0%) | 0.030 | |
Triple negative (family history = Yes (N = 84)) | No | 71 | 13 (18.3%) | 58 (81.7%) | |
Yes | 13 | 9 (69.2%) | 4 (30.8%) | 0.000 | |
Number of relatives with breast and/or ovarian cancer (first and second degree) | Relatives < 2 | 31 | 4 (12.9%) | 27 (87.1%) | NS |
Relatives > = 2 | 64 | 18 (28.1%) | 46 (71.9%) | ||
Family history of breast cancer and/or ovarian cancer (first and second degree) | No | 11 | 11(100%) | 0.063 | |
Yes | 84 | 22 (26.2%) | 62 (73.8%) | ||
Bilateral or second primary breast cancer | no | 80 | 12 (15.0%) | 68 (85.0%) | 0.000 |
yes | 15 | 10 (66.7%) | 5 (33.3%) | ||
Family history of male breast cancer | no | 90 | 20 (22.2%) | 70 (77.8%) | NS |
yes | 5 | 2 (40.0%) | 3 (60.0%) | ||
Family history (age < =40 (N = 50)) | No | 10 | 10(100%) | 0.046 | |
Yes | 40 | 13 (32.5%) | 27 (67.5%) |
FP favor polymorphism, VUS variant of uncertain significance, NS non-significant
aFive patients (patients 061, 063, 020, 070 and 071) were relatives to the index case tested in their families, therefore they were excluded from this analysis, see footnote to Table 2