Table 2.

Clinicopathological parameters in relation to RBBP8 promoter methylation of the BLCA TCGA dataset

	RBBP8 promoter methylationb
	n a	low	high	p valuec
Parameter:
Gender
Male	259	190	69	0.062
Female	94	78	16
Histological tumor grade
Low grade	20	19	1	0.041
High grade	330	247	83
Tumor stage
pT1-pT2	109	86	23	0.49
pT3-pT4	216	163	53
pN status
Negative	212	161	51	0.866
Positive	112	86	26
pM status
Negative	173	131	42	0.138
Positive	7	7	0
RBBP8 mRNAd
Low	200	124	76	≤ 0.001
High	200	175	25

Significant p values are in italics

^aOnly patients with primary bladder cancer without any neoadjuvant therapy were included

^bBased on TCGA 450K DNA methylation analysis

^cFisher’s exact test

^dRBBP8 mRNA expression was dichotomized at the median expression level