Table 4.
Clinicopathological parameters in relation to nuclear RBBP8 protein expression
| RBBP8 IRSb nuclear | |||||
|---|---|---|---|---|---|
| n a | Low | High | p valuec | Spearman r | |
| Parameter: | |||||
| Age at diagnosis | |||||
| < 70 years | 23 | 14 | 9 | 0.213 | − 0.195 |
| ≥ 70 years | 19 | 15 | 4 | ||
| Gender | |||||
| Male | 33 | 25 | 8 | 0.075 | − 0.278 |
| Female | 9 | 4 | 5 | ||
| Tumor subtype | |||||
| Non-invasive papillary | 17 | 8 | 9 | 0.012 | − 0.392 |
| Invasive | 25 | 21 | 4 | ||
| Histological tumor graded | |||||
| Low grade | 12 | 4 | 8 | 0.002 | − 0.489 |
| High grade | 30 | 25 | 5 | ||
| Tumor staged | |||||
| pT1-pT2 | 13 | 9 | 4 | 0.040 | − 0.419 |
| pT3-pT4 | 12 | 12 | 0 | ||
| RBBP8 methylation | |||||
| Low | 11 | 5 | 6 | 0.020 | − 0.564 |
| High | 7 | 7 | 0 | ||
Significant p values are in italics
aOnly patients with primary bladder cancer were included
bScore (IRS) according to Remmele and Stegner [42]
cFisher’s exact test
dAccording to WHO 2004 classification