Table 6.

Clinicopathological parameters in relation to RBBP8 promoter methylation in BLCA associated urine samples

	RBBP8 promoter methylationb
	n a	Low	High	p valuec
Parameter:
Gender
Male	42	31	11	0.687
Female	10	8	2
Histological tumor grade
Low grade	19	17	2	0.046
High grade	30	19	11
Tumor stage
pTa	21	19	2	0.021
pT1-pT4	28	17	11
pN status
Negative	5	3	2	0.931
Positive	8	5	3

Significant p values are in italics

^aOnly patients with primary bladder cancer were included

^bRBBP8 methylation was dichotomized at the Q75 (based on pyrosequencing)

^cFisher’s exact test