Table I.
Subtype-specific pathways related to gastric cancer and common pathways of all subtypes.
| Subtype | KEGG pathway | Counta | Allb | P-valuec |
|---|---|---|---|---|
| Subtype 1 | Renin-angiotensin system | 3 | 17 | 0.007398 |
| Folate biosynthesis | 2 | 10 | 0.014313 | |
| Type II diabetes mellitus | 1 | 9 | 0.01947 | |
| Hedgehog signaling pathway | 2 | 13 | 0.024601 | |
| Helicobacter pylori infection | 1 | 8 | 0.03013 | |
| Subtype 2 | NF-κB signaling pathway | 6 | 9 | 0.01016 |
| Tight junction | 4 | 5 | 0.015905 | |
| Subtype 3 | Fatty acid metabolism | 2 | 3 | 0.044476 |
| Ribosome biogenesis in eukaryotes | 4 | 7 | 0.006553 | |
| Proteasome | 5 | 10 | 0.004685 | |
| Nucleotide excision repair | 3 | 7 | 0.048337 | |
| Cell cycle | 4 | 11 | 0.040908 | |
| Ubiquitin mediated proteolysis | 6 | 11 | 0.001051 | |
| Subtype 4 | PI3K/Akt signaling pathway | 9 | 22 | 0.000675 |
| Vascular smooth muscle contraction | 5 | 10 | 0.004185 | |
| Alzheimer's disease | 4 | 7 | 0.00597 | |
| Focal adhesion | 5 | 11 | 0.006911 | |
| Cardiac muscle contraction | 3 | 5 | 0.015628 | |
| Pertussis | 3 | 5 | 0.015628 | |
| Hypertrophic cardiomyopathy | 4 | 10 | 0.026485 | |
| Dilated cardiomyopathy | 4 | 10 | 0.026485 | |
| Long-term depression | 3 | 6 | 0.028424 | |
| Porphyrin and chlorophyll metabolism | 2 | 3 | 0.042385 | |
| Salmonella infection | 2 | 3 | 0.042385 | |
| Glioma | 2 | 3 | 0.042385 | |
| Dopaminergic synapse | 3 | 7 | 0.045265 | |
| Melanoma | 3 | 7 | 0.045265 |
a
Number of specific genes enriched in the corresponding pathways.
b
Total number of differentially expressed genes.
c
Significance level determined by Fisher's exact test. KEGG, Kyoto Encyclopedia of Genes and Genomes; PI3K, phosphoinositide 3 kinase.