Table I.
Statistical analysis of the CYP2C19 (*2, *3 and *17) allelic and genotypic frequencies (%) among different ethnic groups in Iran.
| A, CYP2C19*2 | ||||||
|---|---|---|---|---|---|---|
| Genotype frequency (%) | ||||||
| Ethnicity | CYP2C19*2 allele frequency (%) | G/G | G/A | A/A | χ2 | P-value |
| Fars | 15.3 | 72.8 (66.1–79.4) | 23.9 (17.2–30.6) | 3.3 (1.1–6.1) | 137.4 | <0.001a |
| Turk | 25.0 | 58.2 (49.1–67.3) | 33.6 (24.5–42.7) | 8.2 (3.6–13.6) | 41.2 | <0.001a |
| Caspian | 9.6 | 83.6 (74–91.8) | 13.7 (5.5–21.9) | 2.7 (0.0 −6.8) | 84.1 | <0.001a |
| Lure | 35.0 | 41.3 (31.3–52.5) | 47.5 (37.5–58.8) | 11.3 (5.0 −18.8) | 18.0 | <0.001a |
| Kurd | 26.3 | 55.8 (46.3–66.3) | 35.8 (25.3–45.3) | 8.4 (3.2–14.7) | 32.2 | <0.001a |
| Total population | 21.4 | 63.6 (59.9–67.7) | 30.1 (26–33.8) | 6.3 (4.5–8.6) | 269.0 | <0.001a |
| B, CYP2C19*3 | ||||||
| Genotype frequency (%) | ||||||
| Ethnicity | CYP2C19*3 allele frequency (%) | G/G | G/A | A/A | χ2 | P-value |
| Fars | 2.9 | 94.2 (89.2–98.3) | 5.8 (1.7–10.8) | 0.0 | 93.6 | <0.001a |
| Turk | 1.8 | 96.3 (91.5–100.0) | 3.6 (0.0–8.5) | 0.0 | 70.4 | <0.001a |
| Caspian | 1.3 | 97.3 (93.3–100.0) | 2.6 (0.0–6.7) | 0.0 | 67.2 | <0.001a |
| Lure | 0.6 | 98.6 (95.9–100.0) | 1.3 (0.0–4.1) | 0.0 | 69.0 | <0.001a |
| Kurd | 1.4 | 97.1 (92.9–100.0) | 2.8 (0.0–7.1) | 0.0 | 62.2 | <0.001a |
| Total population | 1.7 | 96.4 (94.5–98.1) | 3.5 (1.9–5.5) | 0.0 | 362.1 | <0.001a |
| C, CYP2C19*17 | ||||||
| Genotype frequency | ||||||
| Ethnicity | CYP2C19*17 allele frequency (%) | C/C | C/T | T/T | χ2 | P-value |
| Fars | 28.2 | 51.9 (44.2–60.3) | 39.7 (32.1–47.4) | 8.3 (3.8–12.8) | 47.3 | <0.001a |
| Turk | 26.9 | 53.8 (42.9–67.9) | 38.4 (25–50) | 7.6 (1.8–14.3) | 19.9 | <0.001a |
| Caspian | 17.1 | 75.0 (59.4–87.5) | 15.6 (3.1–28.1) | 9.3 (0.0–21.9) | 25.1 | <0.001a |
| Lure | 46.1 | 15.3 (0.0–38.5) | 76.9 (53.8–100.0) | 7.6 (0.0–23.1) | 11.2 | 0.004a |
| Kurd | 21.4 | 64.2 (35.7–85.7) | 28.5 (7.1–50) | 7.1 (0.0–21.4) | 7.0 | 0.030a |
| Total population | 27.1 | 54.2 (48.3- 60.1) | 37.6 (31.7–43.5) | 8.1 (5.2–11.4) | 88.7 | <0.001a |
Different genotype frequencies of each allele were statistically analyzed for each ethnicity using χ2 test, and the genotype frequency of each ethnicity was then compared with the total population (last row).
a
Statistically significant. Values shown in brackets represent 95% confidence interval. CYP2C19, cytochrome P450 2C19.