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. 2018 Jan 17;17(3):4203–4212. doi: 10.3892/mmr.2018.8444

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Figure 3. — Tunicamycin inhibits proliferation and arrests cell cycle of colon cancer cells. (A) Effect of Tunicamycin on proliferation of SW620 cells. (B) Tunicamycin treatment inhibits the expression levels of cyclin D1 CDK1 and CDK2 in SW620 cells. Tunicamycin reduces the number of SW620 cells in (C) M phase and (D) and S phase. (E) Western blotting demonstrated the effects of tunicamycin on the expression levels of Ki67 and PCNA in SW620 cells. (F) Immunofluorescence analysis demonstrated the effect of tunicamycin on the expression levels of Ki67 and PCNA in SW620 cells. Data are expressed as mean ± standard deviation of triplicate experiments. **P<0.01. PCNA, proliferating cell nuclear antigen; CDK1, cyclin dependent kinase 1; CDK2, cyclin dependent kinase 2.