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. 2018 Jan 17;17(3):4203–4212. doi: 10.3892/mmr.2018.8444

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Figure 4. — Tunicamycin suppresses the ERK-JNK signaling pathway in colon cancer cells. (A) Tunicamycin decreased expression of total and phosphorylated ERK in SW620 cells. (B) Tunicamycin decreased expression of total and phosphorylated JNK in SW620 cells. (C) Effects of ERK overexpression on total and phosphorylated JNK in SW620 cells. (D) Effects of ERK overexpression on expression levels of β-catenin and Dkk1 in SW620 cells. Data are expressed as mean ± standard deviation of triplicate experiments. (E) mRNA expression levels of ERK were analyzed by reverse transcription-quantitative polymerase chain reaction in LV-ERK, mock and LV-Con. (F) Protein expression levels of ERK were analyzed by western blotting. **P<0.01. ERKOR, ERK overexpression; Dkk1, Dickkopf-1; ERK, extracellular signal-regulated kinase; JNK, c-JUN N-terminal kinase; Con, control; LV, lentivirus.