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. 2018 Jan 16;17(3):4229–4236. doi: 10.3892/mmr.2018.8437

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — miR-188-3p overexpression stabilized p53 and contributed to the neuroapoptosis induced by sevoflurane. (A) Protein and (B) mRNA levels of p53 were detected by western blot analysis and RT-qPCR, respectively, in the hippocampal tissues of rats that were treated with miR-188-3p mimics or NC miRNA, n=8/group. (C) mRNA and (D) protein levels of p53 in the hippocampal tissues of rats with or without sevoflurane treatment were detected by RT-qPCR and western blot analysis, respectively, n=8/group. (E) SH-SY5Y neuroblastoma cells were exposed to sevoflurane with or without the specific inhibitor of p53, PFT-α, and the cell apoptosis rate was determined by flow cytometry. ***P<0.001 as indicated. miR/miRNA, microRNA; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; NC, negative control; PFT-α, pifithrin-α; ns, not significant.