Table I.
Gene ontology-based similarities between 12 CAD functional classes.
| Categories | GO ID | GO term | No. of categories |
|---|---|---|---|
| Endothelial integrity + gender difference + glucose metabolism + homocysteine metabolism + immune and inflammation + lipid lipoproteins metabolism + metalloproteinase and ECM + uncategorized group + Oxidation-reduction state + renin-angiotensin system + thrombosis | GO:0008270 | Zinc ion binding | 11 |
| Endothelial integrity + glucose metabolism + homocysteine metabolism + immune and inflammation + lipid lipoproteins metabolism + metalloproteinase and ECM + uncategorized group + oxidation-reduction state + thrombosis + VSMCA | GO:0046872 | Metal ion binding | 10 |
| Endothelial integrity + gender difference + glucose metabolism + immune and inflammation + lipid lipoproteins metabolism + metalloproteinase and ECM + uncategorized group + oxidation-reduction state + renin-angiotensin system + VSMCA | GO:0045944 | Positive regulation of transcription from RNA polymerase II | 10 |
| Endothelial integrity + homocysteine metabolism + immune and inflammation + lipid lipoproteins metabolism + metalloproteinase and ECM + uncategorized group + oxidation-reduction state + renin-angiotensin system + thrombosis + VSMCA | GO:0043066 | Negative regulation of apoptotic process | 10 |
| Endothelial integrity + gender difference + glucose metabolism + immune and inflammation + lipid lipoproteins metabolism + metalloproteinase and ECM + uncategorized group + oxidation-reduction state + renin-angiotensin system + thrombosis | GO:0008284 | Positive regulation of cell proliferation | 10 |
| Endothelial integrity + glucose metabolism + immune and inflammation + lipid lipoproteins metabolism + metalloproteinase and ECM + uncategorized group + oxidation-reduction state + renin-angiotensin system + thrombosis + VSMCA | GO:0008285 | Negative regulation of cell proliferation | 10 |
| Endothelial integrity + gender difference + homocysteine metabolism + immune and inflammation + lipid lipoproteins metabolism + uncategorized group + oxidation-reduction state + renin-angiotensin system + thrombosis + VSMCA | GO:0042803 | Protein homodimerization activity | 10 |
| Endothelial integrity + gender difference + homocysteine metabolism + immune and inflammation + lipid lipoproteins metabolism + metalloproteinase and ECM + uncategorized group + oxidation-reduction state + renin-angiotensin system + thrombosis | GO:0006805 | Xenobiotic metabolic process | 10 |
The first column contains the CAD disease functional classes; second and third column represents the common GO ID/Term. The fourth column represents the number of common functional categories for the GO ID. CAD, coronary artery disease; ECM, extracellular matrix; VSMCA, vascular smooth muscle cell activation.