Table II.
Key hub genes selected using topological parameters like BC, degree, and Eigen vector.
| Gene | Node degree | BC | Eigenvector |
|---|---|---|---|
| EGFR | 115 | 5399.54 | 0.1574 |
| ESR1 | 114 | 9262.62 | 0.1403 |
| SRC | 111 | 4376.24 | 0.1564 |
| AKT1 | 110 | 4054.04 | 0.1615 |
| STAT3 | 103 | 3077.36 | 0.1585 |
| IL6 | 103 | 2919.17 | 0.1480 |
| EGF | 96 | 2784.97 | 0.1405 |
| VEGFA | 95 | 2948.25 | 0.1407 |
| IGF1 | 85 | 1561.65 | 0.1385 |
| JUN | 84 | 1996.45 | 0.1276 |
| PIK3CA | 83 | 1194.82 | 0.1343 |
| INS | 82 | 2582.59 | 0.1274 |
| MAPK1 | 82 | 1891.13 | 0.1316 |
| GRB2 | 82 | 1494.86 | 0.1235 |
| PIK3R1 | 80 | 1238.81 | 0.1261 |
| PTPN11 | 75 | 1476.50 | 0.1239 |
BC, node degree, and eigenvector were the topological parameters considered for selection of candidate genes. A cut-off of node degree ≥75, BC ≥1194.82 and eigenvector ≥0.124 were considered as key genes forming backbone of the network. EGFR was the super-hub with the highest centrality. BC, betweenness centrality; EGFR, epidermal growth factor receptor; ESR1, estrogen receptor 1; SRC, Src protein–tyrosine kinase; AKT1, Akt serine-threonine kinase; STAT3, signal transducer and activator of transcription 3; IL, interleukin; EGF, epidermal growth factor; VEGFA, vascular endothelial growth factor A; IGF1, insulin-like growth factor 1; JUN, Jun proto-oncogene, AP-1 transcription factor subunit; PIK3CA, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; INS, insulin; MAPK1, mitogen-activated protein kinases 1; GRB2, growth factor receptor-bound protein 2; PIK3R1, phosphatidylinositol 3-kinase regulatory subunit α; PTPN11, protein tyrosine phosphatase, non-receptor type 11.