Table IV.

Top 10 significant pathways of differentially expressed genes associated with hypertensive nephrosclerosis.

Pathway name	Differentially expressed genes	P-value	False detection rate
Metabolic pathways	65	1.32×10−31	2.69×10−29
PPAR signaling pathway	13	1.29×10−13	1.32×10−11
Protein digestion and absorption	12	4.61×10−11	3.13×10−9
Cell adhesion molecules	14	1.27×10−10	6.50×10−9
Arginine and proline metabolism	10	1.64×10−10	6.68×10−9
Drug metabolism-cytochrome P450	10	2.38×10−9	8.10×10−8
Glycine, serine and threonine metabolism	7	6.81×10−8	1.98×10−6
Proximal tubule bicarbonate reclamation	6	8.44×10−8	2.15×10−6
Tryptophan metabolism	7	1.20×10−7	2.73×10−6
Carbohydrate digestion and absorption	7	2.82×10−7	5.76×10−6