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. 2018 Jan 9;17(3):4483–4489. doi: 10.3892/mmr.2018.8399

Figure 5.

Figure 5.

LDHA-induced glycolysis and cell proliferation can be inhibited by miR-34a. (A) Overexpression of LDHA could increase HCC cell glucose uptake, which was abrogated by miR-34a after cotransfection with miR-34a mimics. *P<0.05 vs. Scramble. (B) Increased lactate production by LDHA was abrogated by miR-34a. *P<0.05 and **P<0.01 vs. Scramble. (C) HuH7 and HCCLM3 cells were transfected as described before. After transfection, the increased cell proliferation of HuH7 and HCCLM3 cells by LDHA was suppressed by miR-34a in a time-dependent manner. **P<0.01 vs. Vec; #P<0.05 and ##P<0.01 vs. LDHA; aP<0.05 and aaP<0.01 vs. miR-34a. (D) miR-34a mimics reversed the invasion capacity which was increased by overexpressed LDHA (magnification, ×200). (E) miR-34a mimics reversed the migration capacity which was increased by overexpressed LDHA (magnification, ×100).