Table 2.
Hazard ratios for epilepsy according to combinations of Apgar scores at five and 10 minutes, singleton term live births in Sweden 1999˗2012
| 5 min Apgar scores | 10 min Apgar scores | Total No of children | No with outcome | Rate/10 000 child years* | Hazard ratio (95% CI)† |
|---|---|---|---|---|---|
| 0-2 | 0-2 | 254 | 2 | 28.5 | 6.4 (1.6 to 25.8) |
| 0-2 | 3-4 | 188 | 4 | 47.7 | 8.5 (2.7 to 26.7) |
| 0-2 | 5-6 | 125 | 1 | 14.0 | NA |
| 0-2 | 7-8 | 101 | 1 | 18.3 | NA |
| 0-2 | 9-10 | 56 | 0 | - | - |
| 3-4 | 0-2 | 5 | 0 | - | - |
| 3-4 | 3-4 | 301 | 5 | 43.4 | 7.9 (2.9 to 21.1) |
| 3-4 | 5-6 | 646 | 4 | 11.0 | 2.5 (0.9 to 6.5) |
| 3-4 | 7-8 | 654 | 4 | 9.4 | 2.1 (0.8 to 5.6) |
| 3-4 | 9-10 | 188 | 0 | - | - |
| 5-6 | 0-2 | 8 | 0 | - | - |
| 5-6 | 3-4 | 7 | 0 | - | - |
| 5-6 | 5-6 | 639 | 5 | 14.2 | 2.5 (1.0 to 6.8) |
| 5-6 | 7-8 | 3324 | 23 | 11.0 | 2.2 (1.4 to 3.4) |
| 5-6 | 9-10 | 2065 | 9 | 6.7 | 1.0 (0.4 to 2.2) |
| 7-8 | 0-2 | 0 | 0 | - | - |
| 7-8 | 3-4 | 0 | 0 | - | - |
| 7-8 | 5-6 | 0 | 0 | - | - |
| 7-8 | 7-8 | 8779 | 44 | 7.9 | 1.5 (1.0 to 2.0) |
| 7-8 | 9-10 | 28 889 | 125 | 6.5 | 1.3 (1.1 to 1.6) |
| 9-10 | 0-2 | 0 | 0 | - | - |
| 9-10 | 3-4 | 0 | 0 | - | - |
| 9-10 | 5-6 | 0 | 0 | - | - |
| 9-10 | 7-8 | 460 | 3 | 10.9 | NA |
| 9-10 | 9-10 | 1 165 023 | 3738 | 5.0 | 1.0 (reference)‡ |
| 9 | 9 | 28 908 | 93 | 4.7 | 0.9 (0.8 to 1.2) |
| 9 | 10 | 99 256 | 361 | 5.3 | 1.1 (1.0 to 1.2) |
| 10 | 9 | 512 | 4 | 13.3 | 2.7 (1.1 to 7.2) |
| 10 | 10 | 1 035 514 | 3280 | 5.0 | 1.0 (reference)§ |
NA=hazard rations could not be reliably calculated because of small number of cases.
*
Total number of years each child contributed to the study.
†
Adjusted for maternal factors (smoking, age at child’s birth, education, country of birth, and diagnoses of epilepsy) and birth characteristics of child (birth order, birth weight for gestational age, gestational age in days, and year of birth).
‡
Reference category for all Apgar values in rows above.
§
Reference category for Apgar values in three rows above.