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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Circ Cardiovasc Genet. 2017 Dec;10(6):e001780. doi: 10.1161/CIRCGENETICS.117.001780

Figure 1. Transmission of the FLNC p.V2297M variant with cardiac phenotypes.

Figure 1

A: Pedigree detailing the spectrum of myocardial phenotypes observed in the family. +/− denotes carrier versus wildtype genotype at amino acid 2297. B: Chromatogram obtained from Sanger sequencing reaction of amplicon obtained from the genomic DNA of II-5. C: Amino acid sequence alignment of FLNC in vertebrate species. Red denotes the p.V2297M variant observed. D: Depiction of FLNC functional domains overlain with known variants and associated phenotypes.