Table 1.
Clinical Characteristics of AF-523 Family Members
| ECG | Echocardiography | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | ID | Sex | Age | PR | QRS | QT | Other | LVEF | LA | LVID | RCM | FLNC mutation | Comment |
| I-1 | 523.01 | M | 58 | − | − | − | AF | − | − | − | NA | Stroke at age 42 | |
| I-2 | 523.02 | F | 72 | − | − | − | − | − | − | NA | No known cardiac disease | ||
| II-1 | 523.1 | M | 25 | − | − | − | AF | − | − | − | NA | SCD at age 25 | |
| II-2 | 329 | F | 51 | − | 83 | 402 | AF | 70 | 46 | 38 | + | + | Sick sinus syndrome, pacemaker, stroke |
| II-4 | 523.3 | M | 60 | − | − | − | − | − | − | NA | |||
| II-5 | 523.4 | F | 51 | − | 98 | 455 | AF, VT | 67 | 49 | 41 | + | + | Pacemaker, ASD, stroke |
| II-6 | 523.5 | F | 54 | − | − | − | − | − | − | − | |||
| II-7 | 523.6 | M | 44 | 238 | 104 | 410 | AF | 60 | 41 | 38 | + | + | Pulmonary hypertension, ICD |
| III-2 | 523.21 | F | 37 | 214 | 86 | 498 | AF, T wave inversions | 52 | 38 | 47 | ? | + | CHF at age |
| III-3 | 523.31 | − | − | − | − | − | − | − | |||||
| III-4 | 523.61 | F | 17 | 114 | 80 | 459 | 71 | 33 | 43 | + | VSD | ||
| III-5 | 523.62 | F | 15 | 144 | 76 | 457 | 66 | 34 | 48 | − | |||
| IV-1 | 523.211 | F | 20 | − | − | − | − | − | − | − | |||
| IV-2 | 523.212 | F | 19 | 118 | 66 | 427 | 62 | 28 | 39 | − | |||
| IV-3 | 523.213 | F | 14 | 146 | 78 | 412 | T wave inversions | 61 | − | 47 | + | Papillary muscle hypertrophy | |
AF, atrial fibrillation; VT, ventricular tachycardia; LVEF, left ventricular ejection fraction; LA, left atrial diameter; CM, cardiomyopathy; ICD, implanted cardioverter-defibrillator; CHF, congestive heart failure
ECG and echocardiography parameters were shown from the day of study enrollment