. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: J Thromb Haemost. 2017 Nov 20;16(1):131–141. doi: 10.1111/jth.13887

Table 2.

Thrombin generation parameters

	Buffer (n = 7)	FXIII (n = 7)	FVIII (n = 7)	FVIII + FXIII (n = 7)
Lag time (min)	12.0 ± 2.9	10.2 ± 1.6	8.1 ± 0.6	8.6 ± 0.8
Time to peak (min)	28.4 ± 3.1	25.0 ± 1.8	13.6 ± 0.6*	14.3 ± 1.1*
Velocity index (nM min⁻¹)	0.29 ± 0.1	0.44 ± 0.7	14.0 ± 2.5*	13.1 ± 2.4*
Peak thrombin (nM)	4.5 ± 0.6	6.1 ± 1.0	68.0 ± 7.0*	68.7 ± 9.4*
ETP (nM min)	95.5 ± 9.5	117.5 ± 16.0	638.1 ± 34.6*	684.1 ± 70.5*

ETP, endogenous thrombin potential. Mean ± standard error of the mean. P < 0.05 as compared with buffer-treated samples via repeated-measure ANOVA with Dunn’s or Holm–Sidak multiple comparisons for non-normal and normal distributions.