Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 10;8:3. doi: 10.1038/s41398-017-0060-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Persistent bursting in neonatal PCP-treated rats underlies abnormal spatiotemporal activity propagation. a PCP treatment increases spatial activity propagation specifically by increasing repeat (rather than new) neuronal activations. Branching parameter measured in number of neurons (total, new, and repeat) for different treatment groups. b Schematic representation of spatiotemporal activity propagation in SAL vs. PCP treated rats. Empty triangles represent quiescent neurons; filled triangles, active neurons; arrows, activity propagation. The black cascade shows a representative pattern of feedforward activity; in PCP treated rats, aberrant repeat activity (red triangles) caused by persistent bursting is superimposed on this cascade. c PCP-treated rats show shallower distributions in burst lengths. Left, distributions of burst lengths for different treatment groups. Distributions were plotted after pooling all bursts per movie, then averaged. Right, slope exponents for burst length distributions for different treatment groups. d PCP treatment leads to more persistent bursts of activity. Fraction of bursts with length greater than one frame for different treatment groups. e Removing persistent bursts rescues the PCP-induced increase in pairwise cross-correlation. Complementary cumulative distributions of pairwise cross-correlations for SAL, PCP, and PCP with repeat activations removed. Distributions were plotted for each movie per group then averaged. f KS distance, power law exponent, and branching parameter for PCP, and PCP with repeat activations removed. Error bars indicate s.e.m; *, P < 0.05, **, P < 0.01, ***, P < 0.001