Fig. 4.

Neonatal PCP treatment-induced changes in avalanche dynamics are rescued by enhancing GABAergic signaling, but not reproduced by inhibiting PVins. a Baclofen inhibts network activity. Mean λ rates for each group. b Baclofen rescues the PCP-induced increase in pairwise cross-correlation. Distributions of pairwise cross-correlations for each group. Distributions were plotted for each movie per group then averaged. Bars show bins with significant group differences (Wilcoxon’s rank sum test, P < 0.05; magenta, SAL vs. PCP, cyan, PCP vs. PCP + baclofen). Inset, mean CDFs. c Branching parameter for different treatment groups. d Baclofen rescues PCP-induced persistent bursting. Slope exponents for burst length distributions for different treatment groups. e YC2.60, NpHR3.0, and PV labeling in AAV-injected PV-Cre rats. Scale bar, left, 100 µm. right, 20 µm. f PVin inhibition increases network activity. Mean λ rates from movies of identical regions without (Ctrl.) and with LED stimulation. g PVin inhibition decreases pairwise cross-correlations. Distributions of pairwise cross-correlations for both stimulation groups. Distributions were plotted for each movie per group then averaged. Bars show bins with significant group differences (Wilcoxon’s rank sum test, P < 0.05). h PVin inhibition produces steeper distributions in burst lengths. Slope exponents for burst length distributions for both stimulation groups. Error bars and shaded regions indicate s.e.m; *, P < 0.05