Table 2.

Firing frequencies of L5PCs and pacemaking frequencies of SANCs are correlated for Na⁺ channel and HCN1 variants, but anticorrelated for Ca²⁺ channel and Ca²⁺ transporter variants

(A) Na+ and HCN channel variants
	Hay	Almog
Kharche	0.4965	0.7477
Severi	0.5031	0.7818

(B) Ca2+ channel and transporter variants
	Hay	Almog
Kharche	−0.5168	−0.5971
Severi	−0.7700	−0.7905

(C) All variants
	Hay	Almog	Kharche	Severi
Hay	1	0.6896	−0.4364	−0.7223
Almog	0.6896	1	−0.4233	−0.6501
Kharche	−0.4364	−0.4233	1	0.6645
Severi	−0.7223	−0.6501	0.6645	1

The table shows the correlation coefficients between the firing or pacemaking frequencies of $ϵ\mathbf{=}-\frac{1}{4}$ variants (see Fig. 3), as predicted by the different models. A: Only data from SCN1A and HCN1 variants included. B: Only data from CACNA1C, CACNA1D, CACNB2, CACNA1I and ATP2A2 variants included. C: All variants included. The variants that were not applicable for L5PC models (see the Supplementary Table S2 entries corresponding to studies^47,48) were omitted. The relatively strong anticorrelations between L5PC and SANC model data in (C) reflect the fact that majority (80) of the variants (94 in total) operated on Ca²⁺ channels and transporters