Table 3.
Total actin, F-actin, G-actin, and phalloidin-binding levels in schizophrenia and comparison subjects
| Comparison | Schizophrenia | Test statistic | p | |
|---|---|---|---|---|
| ACTraw | 2.84 ± 0.68 | 2.93 ± 0.64 | t(28) = 0.38 | |
| F-actin/ACTraw | 0.56 ± 0.05 | 0.46 ± 0.07 | t(28) = 4.39 | 0.0001 |
| G-actin/ACTraw | 0.44 ± 0.05 | 0.54 ± 0.07 | t(28) = 4.39 | 0.0001 |
| F-actin/G-actin | 1.30 ± 0.26 | 0.89 ± 0.07 | t(28) = 4.37 | 0.0002 |
| ACTnorm | 1.88 ± 0.47 | 1.92 ± 0.43 | t(28) = 0.20 | |
| F-actin/ β-tubulin | 1.05 ± 0.25 | 0.87 ± 0.21 | t(28) = 2.11 | 0.0439 |
| G-actin/ β-tubulin | 0.83 ± 0.24 | 1.04 ± 0.28 | t(28) = 2.19 | 0.0373 |
| Phalloidin (F-actin) | 67.95 ± 16.12 | 47.65 ± 15.15 | t(28) = 3.56 | 0.0014 |
Total raw actin (ACTraw), β-tubulin-normalized total actin (ACTnorm), and reported ratios are calculated as described in Methods-Data Analysis. Phalloidin (F-actin) is calculated as the average fluorescence value (arbitratry units) for each subject less the average fluorescence of negative control samples containing only phalloidin. Data are reported as means ± standard deviation