Table 4.
Total actin, F-actin, G-actin, and phalloidin-binding levels in haloperidol and vehicle-treated rats
| Control | Haloperidol | Test statistic | |
|---|---|---|---|
| ACTraw | 2.97 ± 0.03 | 3.01 ± 0.03 | t(18) = 0.37 |
| F-actin/ACTraw | 0.51 ± 0.01 | 0.50 ± 0.02 | t(18) = 1.22 |
| G-actin/ACTraw | 0.49 ± 0.01 | 0.50 ± 0.02 | t(18) = 0.70 |
| F-actin/G-actin | 0.99 ± 0.06 | 0.98 ± 0.04 | t(18) = 0.31 |
| ACTnorm | 1.97 ± 0.06 | 1.99 ± 0.06 | t(18) = 0.70 |
| F-actin/ β-tubulin | 0.98 ± 0.03 | 1.00 ± 0.04 | t(18) = 1.63 |
| G-actin/ β-tubulin | 0.99 ± 0.06 | 0.98 ± 0.04 | t(18) = 0.31 |
| Phalloidin (F-actin) | 58.27 ± 10.61 | 58.13 ± 8.93 | t(18) = 0.03 |
Total raw actin (ACTraw), β-tubulin-normalized total actin (ACTnorm), and reported ratios are calculated as described in Methods-Data Analysis. Phalloidin (F-actin) is calculated as the average fluorescence value (arbitratry units) for each subject less the average fluorescence of negative control samples containing only phalloidin. Data are reported as means ± standard deviation; no variables were significantly different between treatment conditions